Ccdc159^em1Yingz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc159^em1Yingz
• Name: coiled-coil domain containing 159; endonuclease-mediated mutation 1, Ying Zheng
• MGI ID: MGI:7703515
• Gene: Ccdc159 Location: Chr9:21838767-21847168 bp, + strand Genetic Position: Chr9, 7.92 cM, cytoband A4
• Alliance: Ccdc159^em1Yingz page

Mutation origin

• Strain of Origin: C57BL/6NCr

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination created a 4,733 bp deletion spanning exons 4 - 11. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:351297)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc159 Mutation: 16 strains or lines available

References

• Original: J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894
• All: 1 reference(s)