Styxl1^em2Xjg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Styxl1^em2Xjg
• Name: serine/threonine/tyrosine interacting-like 1; endonuclease-mediated mutation 2, Xuejiang Guo
• MGI ID: MGI:7703729
• Synonyms: Styxl1^delta74bp
• Gene: Styxl1 Location: Chr5:135776074-135807239 bp, - strand Genetic Position: Chr5, 75.38 cM
• Alliance: Styxl1^em2Xjg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exon 5 created a 4 bp deletion. Targeted protein quantification based on parallel reaction monitoring confirmed the absence of expression in testes from homozygous mice. (J:351148)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Styxl1 Mutation: 24 strains or lines available

References

• Original: J:351148 Chen Y, et al., STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation. Nat Commun. 2024 Jan 2;15(1):44
• All: 1 reference(s)