App^em8Msasn
Endonuclease-mediated Allele Detail

Summary

• Symbol: App^em8Msasn
• Name: amyloid beta precursor protein; endonuclease-mediated mutation 7, Michael Sasner
• MGI ID: MGI:7703878
• Synonyms: APP^SFL)
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^em8Msasn page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 technology, the humanizing A(beta) region R684H, F681Y, and G676R mutations, and the KM670/671NL (Swedish) mutation, as well as the I716V (Florida) and V717I (London) mutations were introduced in the mouse App (amyloid beta (A4) precursor protein) gene. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any App Mutation: 103 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)