Mtfmt^em1Heb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mtfmt^em1Heb
• Name: mitochondrial methionyl-tRNA formyltransferase; endonuclease-mediated mutation 1, Bin He
• MGI ID: MGI:7704181
• Gene: Mtfmt Location: Chr9:65343064-65360336 bp, + strand Genetic Position: Chr9, 35.31 cM, cytoband D
• Alliance: Mtfmt^em1Heb page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using guide RNAs created a deletion allele removing exons 2-4. (J:334467)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtfmt Mutation: 18 strains or lines available

References

• Original: J:334467 Sun X, et al., Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice. Int J Mol Sci. 2023 Mar 22;24(6)
• All: 1 reference(s)