Zbtb21^em1Jhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zbtb21^em1Jhan
• Name: zinc finger and BTB domain containing 21; endonuclease-mediated mutation 1, Jiahuai Han
• MGI ID: MGI:7705190
• Gene: Zbtb21 Location: Chr16:97746993-97763850 bp, - strand Genetic Position: Chr16, 57.75 cM, cytoband C3-4
• Alliance: Zbtb21^em1Jhan page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeted the largest exon region for deletion. (J:351206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb21 Mutation: 37 strains or lines available

References

• Original: J:351206 Qiao M, et al., ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome. Sci Adv. 2024 Jul 5;10(27):eadm7373
• All: 1 reference(s)