Gt(ROSA)26Sor^{em1(CAG-Zbtb21,-GFP)Jhan}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Zbtb21,-GFP)Jhan}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jiahuai Han
• MGI ID: MGI:7705191
• Synonyms: CAG-Zbtb21, Zbtb21^LSL-Tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Zbtb21,-GFP)Jhan} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-Zbtb21,-GFP)Jhan} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zbtb21 (MGI:1927240)

• Mutation details: CRISPR/Cas9 technology inserted a CAG promoter, loxP-flanked stop cassette (LSL), Zbtb21 gene, IRES, and GFP into the locus. (J:351206)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:351206 Qiao M, et al., ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome. Sci Adv. 2024 Jul 5;10(27):eadm7373
• All: 1 reference(s)