Kif18a^tm1.1Lgr
Targeted Allele Detail

Summary

• Symbol: Kif18a^tm1.1Lgr
• Name: kinesin family member 18A; targeted mutation 1.1, Laura Reinholdt
• MGI ID: MGI:7705503
• Synonyms: Kif18a^GFPin
• Gene: Kif18a Location: Chr2:109111165-109172094 bp, + strand Genetic Position: Chr2, 56.55 cM
• Alliance: Kif18a^tm1.1Lgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:352185
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector floxed exon 2 and inserted two GFP exons and an artificial intron inserted immediately after the start codon to produce Nterminally tagged fusion protein. Flp-mediated recombination removed the selection cassette. (J:352185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif18a Mutation: 63 strains or lines available

References

• Original: J:352185 Mihajlovic AI, et al., Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs. EMBO Rep. 2023 Nov 6;24(11):e57227
• All: 1 reference(s)