Stk32a^em1Mdea
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stk32a^em1Mdea
• Name: serine/threonine kinase 32A; endonuclease-mediated mutation 1, Michael R Deans
• MGI ID: MGI:7707448
• Gene: Stk32a Location: Chr18:43340762-43450546 bp, + strand Genetic Position: Chr18, 23.17 cM
• Alliance: Stk32a^em1Mdea page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F1/J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNAs 5'-UAGAAAUGACCAUGGUGCAU-3' and 5'-UACAGUGUAUCUAAGGAUAG-3' deleted exon 2, which contains the translational start and N-myristoyl glycine and ATP-binding motifs required for function. (J:338146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk32a Mutation: 35 strains or lines available

References

• Original: J:338146 Jia S, et al., The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear. Elife. 2023 May 5;12
• All: 1 reference(s)