Deptor^tm1.2Ysun
Targeted Allele Detail

Summary

• Symbol: Deptor^tm1.2Ysun
• Name: DEP domain containing MTOR-interacting protein; targeted mutation 1.2, Yi Sun
• MGI ID: MGI:7707725
• Synonyms: DEPTOR^KO
• Gene: Deptor Location: Chr15:54975824-55122667 bp, + strand Genetic Position: Chr15, 21.96 cM
• Alliance: Deptor^tm1.2Ysun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297884
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT-flanked neomycin selection cassette was inserted upstream of exon 6 and a second loxP site was inserted downstream of exon 7. The neomycin cassette was removed via flp-mediated recombination. Exons 6-7 were deleted via cre-mediated recombination. Western blot analysis confirmed the absence of protein in brain and liver. (J:297884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Deptor Mutation: 29 strains or lines available

References

• Original: J:297884 Chen X, et al., DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020 Feb;39(7):1557-1571
• All: 3 reference(s)