Tmem268^em1Cheyy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem268^em1Cheyy
• Name: transmembrane protein 268; endonuclease-mediated mutation 1, Yingyu Chen
• MGI ID: MGI:7709327
• Gene: Tmem268 Location: Chr4:63477018-63504594 bp, + strand Genetic Position: Chr4, 34.02 cM
• Alliance: Tmem268^em1Cheyy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs (5-GAGCCTCCCACAGATCCTGGTGG-3, 5-TCCTGGCTGGGGGCAAGGTAAGG-3) targeting exon 3 created an 85 bp deletion. (J:350812)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem268 Mutation: 23 strains or lines available

References

• Original: J:350812 Duan M, et al., Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling. EMBO Rep. 2024 Jun;25(6):2550-2570
• All: 1 reference(s)