Zup1^em1Lisi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zup1^em1Lisi
• Name: zinc finger containing ubiquitin peptidase 1; endonuclease-mediated mutation 1, Siji Li
• MGI ID: MGI:7709433
• Gene: Zup1 Location: Chr10:33795138-33827265 bp, - strand Genetic Position: Chr10, 18.85 cM, cytoband B1
• Alliance: Zup1^em1Lisi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting introns 2 and 4 created a deletion removing exons 3 and 4. (J:350802)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zup1 Mutation: 34 strains or lines available

References

• Original: J:350802 Li T, et al., MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation. Int Immunopharmacol. 2024 Mar 8;131:111819
• All: 1 reference(s)