Hsf5^em1Asla
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hsf5^em1Asla
• Name: heat shock transcription factor family member 5; endonuclease-mediated mutation 1, Muhammad Asla
• MGI ID: MGI:7709565
• Gene: Hsf5 Location: Chr11:87507990-87550368 bp, + strand Genetic Position: Chr11, 52.16 cM
• Alliance: Hsf5^em1Asla page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 2 to 3. Western blot analysis confirmed the absence of protein in testes. (J:352587)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsf5 Mutation: 24 strains or lines available

References

• Original: J:352587 Barutc AR, et al., Heat shock factor 5 establishes the male germ-line meiotic sex chromosome inactivation through regulation of Smarca4. Heliyon. 2023 May;9(5):e15194
• All: 1 reference(s)