Adam29^em1Otin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adam29^em1Otin
• Name: a disintegrin and metallopeptidase domain 29; endonuclease-mediated mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:7710881
• Gene: Adam29 Location: Chr8:56323947-56359983 bp, - strand Genetic Position: Chr8, 29.68 cM
• Alliance: Adam29^em1Otin page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 technology using sgRNAs 5'-AGTGTTCACCTACTCTGATC-3' and 5'-AGTCACCCTCCACATAACCT-3' generated a 58 bp deletion in the coding exon. (J:353244)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam29 Mutation: 39 strains or lines available

References

• Original: J:353244 Campos-Iglesias D, et al., Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing. iScience. 2024 Jun 21;27(6):110135
• All: 1 reference(s)