Ubl7^em1Fanm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ubl7^em1Fanm
• Name: ubiquitin-like 7 (bone marrow stromal cell-derived); endonuclease-mediated mutation 1, Min Fang
• MGI ID: MGI:7710910
• Gene: Ubl7 Location: Chr9:57818262-57837251 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband C
• Alliance: Ubl7^em1Fanm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs created a deletion removing exon 4. PCR and western blot analysis confirmed the absence of expression in several organs, including the lung, spleen, liver, and kidney, from homozygous mice. (J:349835)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubl7 Mutation: 25 strains or lines available

References

• Original: J:349835 Jiang W, et al., UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS. Cell Rep. 2023 Mar 28;42(3):112272
• All: 1 reference(s)