Fen1^tm5.1Bhsh
Targeted Allele Detail

Summary

• Symbol: Fen1^tm5.1Bhsh
• Name: flap structure specific endonuclease 1; targeted mutation 5.1, Binghui Shen
• MGI ID: MGI:7711261
• Synonyms: Fen1^S187A
• Gene: Fen1 Location: Chr19:10176496-10181533 bp, - strand Genetic Position: Chr19, 6.54 cM
• Alliance: Fen1^tm5.1Bhsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct introduced the mutation responsible for the amino acid substitution of serine with alanine at position 187 (S187A). Recombination removed the selection cassette inserted upstream of the modified sequence. (J:268403)

Expression

In Mice Carrying this Mutation:

126 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fen1 Mutation: 32 strains or lines available

References

• Original: J:268403 Zhou L, et al., Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147
• All: 1 reference(s)