Zdhhc20^em1.1Jdo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zdhhc20^em1.1Jdo
• Name: zinc finger, DHHC domain containing 20; endonuclease-mediated mutation 1.1, Julian Downward
• MGI ID: MGI:7711280
• Gene: Zdhhc20 Location: Chr14:58070160-58127733 bp, - strand Genetic Position: Chr14, 30.51 cM, cytoband C2
• Alliance: Zdhhc20^em1.1Jdo page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/EGE mediated recombination inserted loxP sites in non-conserved regions in introns 4 and 7. Cre mediated recombination removed exons 5-7. (J:348743)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Zdhhc20^em1.1Jdo/Zdhhc20^em1.1Jdo	involves: BALB/c * C57BL/6

Phenotypes:

Affected Systems	hm1
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normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc20 Mutation: 41 strains or lines available

References

• Original: J:348743 Tomic G, et al., Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. Cell Rep. 2024 May 10;43(5):114224
• All: 1 reference(s)