Slfn9^em1Liudp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slfn9^em1Liudp
• Name: schlafen 9; endonuclease-mediated mutation 1, Depei Liu
• MGI ID: MGI:7711292
• Gene: Slfn9 Location: Chr11:82869216-82882656 bp, - strand Genetic Position: Chr11, 50.3 cM
• Alliance: Slfn9^em1Liudp page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 31 bp deletion in the coding region. (J:351319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slfn9 Mutation: 41 strains or lines available

References

• Original: J:351319 Zhang P, et al., Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA. Sci Immunol. 2024 Jun 14;9(96):eadj5465
• All: 1 reference(s)