Cfdp1^tm1Dkwpd
Targeted Allele Detail

Summary

• Symbol: Cfdp1^tm1Dkwpd
• Name: craniofacial development protein 1; targeted mutation 1, Thomas Diekwisch
• MGI ID: MGI:7711521
• Gene: Cfdp1 Location: Chr8:112495123-112580923 bp, - strand Genetic Position: Chr8, 57.98 cM
• Alliance: Cfdp1^tm1Dkwpd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:349245
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A lacZ-neo cassette was inserted replacing a 376 bp region of exon 1 via homologous recombination. (J:349245)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfdp1 Mutation: 121 strains or lines available

References

• Original: J:349245 Gopinathan G, et al., CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation. PLoS Biol. 2024 Apr;22(4):e3002574
• All: 1 reference(s)