Gsap^tm1.2Pggd
Targeted Allele Detail

Summary

• Symbol: Gsap^tm1.2Pggd
• Name: gamma-secretase activating protein; targeted mutation 1.2, Paul Greengard
• MGI ID: MGI:7713179
• Gene: Gsap Location: Chr5:21391253-21520130 bp, + strand Genetic Position: Chr5, 9.83 cM
• Alliance: Gsap^tm1.2Pggd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331150
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and F3-flanked puromycin selection cassette were inserted upstream of exon 9 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 11. The selection cassettes were removed via flp-mediated recombination. Exons 9-11 were removed via cre-mediated recombination. (J:331150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsap Mutation: 69 strains or lines available

References

• Original: J:331150 Xu P, et al., GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 2021 Aug 2;218(8)
• All: 1 reference(s)