Trim41^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim41^em1Osb
• Name: tripartite motif-containing 41; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7713327
• Synonyms: deltaRING-Trim41
• Gene: Trim41 Location: Chr11:48697231-48708180 bp, - strand Genetic Position: Chr11, 28.78 cM
• Alliance: Trim41^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 180 bp deletion and inserted an HA tag in the RING domain, disrupting the RING domain. This allele loses only ubiquitin ligase activity, not interaction with target proteins. (J:325726)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim41 Mutation: 15 strains or lines available

References

• Original: J:325726 Oura S, et al., Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. PLoS Genet. 2022 Jun;18(6):e1010241
• All: 1 reference(s)