Tmem151a^em#Zyw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem151a^em#Zyw
• Name: transmembrane protein 151A; endonuclease-mediated mutation, Zhi-Ying Wu
• MGI ID: MGI:7713407
• Gene: Tmem151a Location: Chr19:5120859-5135519 bp, - strand Genetic Position: Chr19, Syntenic
• Alliance: Tmem151a^em#Zyw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs targeting exon 1 and exon 2 generated insertion-deletion mutations which result in premature stop of protein translation. The pound symbol (#) symbol is used because it is not indicated if a specific insertion-deletion mutation was identified and used or if several mutations were identified and the lines were pooled. (J:330440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem151a Mutation: 19 strains or lines available

References

• Original: J:330440 Li HF, et al., TMEM151A variants cause paroxysmal kinesigenic dyskinesia. Cell Discov. 2021 Sep 13;7(1):83
• All: 1 reference(s)