Smg5^tm1.2Litl
Targeted Allele Detail

Summary

• Symbol: Smg5^tm1.2Litl
• Name: SMG5 nonsense mediated mRNA decay factor; targeted mutation 1.2, Tangliang Li
• MGI ID: MGI:7716509
• Synonyms: Smg5^delta
• Gene: Smg5 Location: Chr3:88243567-88269645 bp, + strand Genetic Position: Chr3, 38.8 cM
• Alliance: Smg5^tm1.2Litl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:353570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 4. The neomycin cassette was removed via flp-mediated recombination. Exons 2-4 were removed via cre-mediated recombination in the germline. (J:353570)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smg5 Mutation: 57 strains or lines available

References

• Original: J:353570 Chen C, et al., RNA Surveillance Factor SMG5 Is Essential for Mouse Embryonic Stem Cell Differentiation. Biomolecules. 2024 Aug 17;14(8)
• All: 1 reference(s)