Car1^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Car1^tm1.1Nju
• Name: carbonic anhydrase 1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7718420
• Synonyms: Car1^-
• Gene: Car1 Location: Chr3:14831274-14873425 bp, - strand Genetic Position: Chr3, 3.18 cM
• Alliance: Car1^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336771
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-En2-SA-IRES-LacZ-LoxP-FRT-loxP cassette was inserted into intron 2, 0.5 kb upstream of exon 3, and a third loxP site was inserted into intron 3, 0.3 kb downstream of exon 3. Cre-mediated recombination deleted exon 3. (J:336771)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Car1 Mutation: 12 strains or lines available

References

• Original: J:336771 Cheng K, et al., Upregulation of carbonic anhydrase 1 beneficial for depressive disorder. Acta Neuropathol Commun. 2023 Apr 3;11(1):59
• All: 1 reference(s)