Nsun3^tm1.2Tomik
Targeted Allele Detail

Summary

• Symbol: Nsun3^tm1.2Tomik
• Name: NOL1/NOP2/Sun domain family member 3; targeted mutation 1.2, Kazuhito Tomizawa
• MGI ID: MGI:7718595
• Gene: Nsun3 Location: Chr16:62552807-62607181 bp, - strand Genetic Position: Chr16, 36.43 cM
• Alliance: Nsun3^tm1.2Tomik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336777
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 4. The neomycin selection cassette was removed via cre-mediated recombination. Exon 4 was deleted via cre-mediated recombination in the germline. (J:336777)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsun3 Mutation: 17 strains or lines available

References

• Original: J:336777 Murakami Y, et al., NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice. Commun Biol. 2023 Mar 22;6(1):307
• All: 1 reference(s)