Slc35c2^tm1.1Pst
Targeted Allele Detail

Summary

• Symbol: Slc35c2^tm1.1Pst
• Name: solute carrier family 35, member C2; targeted mutation 1.1, Pamela Stanley
• MGI ID: MGI:7720232
• Gene: Slc35c2 Location: Chr2:165118474-165129789 bp, - strand Genetic Position: Chr2, 85.53 cM
• Alliance: Slc35c2^tm1.1Pst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:354047
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo-tk cassette was inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 4. Western blot analysis confirmed the absence of protein in testis lysates from homozygous males. (J:354047)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc35c2 Mutation: 17 strains or lines available

References

• Original: J:354047 Lu L, et al., In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2. J Biol Chem. 2023 Dec;299(12):105406
• All: 1 reference(s)