Rnase4^em1Zpxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnase4^em1Zpxu
• Name: ribonuclease, RNase A family 4; endonuclease-mediated mutation 1, Zhengping Xu
• MGI ID: MGI:7735214
• Gene: Rnase4 Location: Chr14:51328534-51343608 bp, + strand Genetic Position: Chr14, 26.37 cM, cytoband C1
• Alliance: Rnase4^em1Zpxu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: TALEN technology generated a 2 bp (TG) insertion (c.49_50insTG) in exon 2 resulting in premature translation termination. (J:354138)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnase4 Mutation: 20 strains or lines available

References

• Original: J:354138 Sun J, et al., Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis. Nat Commun. 2024 Jul 10;15(1):5778
• All: 1 reference(s)