Styxl2^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Styxl2^tm1.1Nju
• Name: serine/threonine/tyrosine interacting like 2; endonuclease-mediated mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7736257
• Synonyms: Styxl2 KO
• Gene: Styxl2 Location: Chr1:165925717-165955467 bp, - strand Genetic Position: Chr1, 73.45 cM
• Alliance: Styxl2^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:351096
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed exons 3-5. Cre-mediated recombination removed exons 3-5. Western blot analysis of soluble tissue lysates from E14.5 limbs confirmed the complete absence of protein expression in skeletal muscles of homozygous mutant mice. (J:351096)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Styxl2 Mutation: 62 strains or lines available

References

• Original: J:351096 Chen X, et al., Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. Elife. 2024 Jun 3;12
• All: 1 reference(s)