Oprk1^tm1(cre)Ddg
Targeted Allele Detail

Summary

• Symbol: Oprk1^tm1(cre)Ddg
• Name: opioid receptor, kappa 1; targeted mutation 1, David D Ginty
• MGI ID: MGI:7736362
• Synonyms: Oprk1^T2a-Cre
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^tm1(cre)Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:348651
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Oprk1^tm1(cre)Ddg expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oprk1 (MGI:97439)

• Mutation details: The T2a-cre cassette followed by STOP and frt flanked neo cassette was inserted directly upstream of the stop codon in the last exon of the Trpm8 gene. (J:348651)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oprk1 (mouse) Summary of all recombinase alleles driven by Oprk1. Alliance mouse Oprk1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 30 strains or lines available

References

• Original: J:348651 Qi L, et al., A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell. 2024 Mar 14;187(6):1508-1526.e16
• All: 1 reference(s)