Lrrk2^em1Yue
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrk2^em1Yue
• Name: leucine-rich repeat kinase 2; endonuclease-mediated mutation 1, Zhenyu Yue
• MGI ID: MGI:7737634
• Synonyms: LRRK2^N2081D
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^em1Yue page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A missense mutation (nucleotide GAGTTT to GAATTC; conserved in both mouse and human) and a silent mutation creating an EcoRI site were introduced to exon 41 of the mouse Lrrk2 gene using CRISPR/cas9 methodologies. (J:101977, J:354845)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:354845 Heaton GR, et al., Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant. bioRxiv. 2024 Sep 5
• All: 2 reference(s)