Tox2^em1Cdon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tox2^em1Cdon
• Name: TOX high mobility group box family member 2; endonuclease-mediated mutation 1, Chen Dong
• MGI ID: MGI:7738442
• Gene: Tox2 Location: Chr2:163045047-163166092 bp, + strand Genetic Position: Chr2, 84.14 cM
• Alliance: Tox2^em1Cdon page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNA 5'-TGTCACGGCCTTGCGCCCAA-3' generated a 14 bp deletion in exon 3 resulting in a frameshift and early termination of translation. (J:290926)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tox2 Mutation: 31 strains or lines available

References

• Original: J:290926 Xu W, et al., The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility. Immunity. 2019 Nov 19;51(5):826-839.e5
• All: 1 reference(s)