Tmem106a^em1Cheyy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem106a^em1Cheyy
• Name: transmembrane protein 106A; endonuclease-mediated mutation 1, Yingyu Chen
• MGI ID: MGI:7738707
• Synonyms: Tmem106a^-, Tmem106a KO
• Gene: Tmem106a Location: Chr11:101473068-101482612 bp, + strand Genetic Position: Chr11, 65.44 cM
• Alliance: Tmem106a^em1Cheyy page

Mutation origin

• Strain of Origin: (C57BL/6J x FVB/N)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing was used to generate a 148 base pairs (bp) deletion encompassing the the start codon in the exon 3. (J:345342)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem106a Mutation: 19 strains or lines available

References

• Original: J:345342 Zhang X, et al., Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-kappaB signaling pathways in macrophages. Clin Exp Immunol. 2021 Jan;203(1):125-136
• All: 1 reference(s)