Hoxa11osem1Kaf
Endonuclease-mediated Allele Detail
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Symbol: |
Hoxa11osem1Kaf |
Name: |
homeobox A11, opposite strand; endonuclease-mediated mutation 1, Katherine A Fitzgerald |
MGI ID: |
MGI:7738733 |
Synonyms: |
HOXA11os-KO |
Gene: |
Hoxa11os Location: Chr6:52222013-52226770 bp, + strand Genetic Position: Chr6, 25.4 cM
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Alliance: |
Hoxa11osem1Kaf page
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: CRISPR-Cas9 genome editing technology was used to introduce a short 49-bp synthetic polyadenylation signal (spA) in exon 1 proximal to the transcription start site of HOXA11os. This results in a complete loss of HOXA11os transcripts 1 and 2 in the distal colon with no effect on the expression of the proximal protein-coding gene HOXA11 under basal or colitis conditions.
(J:344661)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hoxa11os Mutation: |
0 strains or lines available
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Original: |
J:344661 Shmuel-Galia L, et al., The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis. Cell Metab. 2023 Aug 8;35(8):1441-1456.e9 |
All: |
1 reference(s) |
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