Hoxa11os^em1Kaf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxa11os^em1Kaf
• Name: homeobox A11, opposite strand; endonuclease-mediated mutation 1, Katherine A Fitzgerald
• MGI ID: MGI:7738733
• Synonyms: HOXA11os-KO
• Gene: Hoxa11os Location: Chr6:52222013-52226770 bp, + strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa11os^em1Kaf page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-Cas9 genome editing technology was used to introduce a short 49-bp synthetic polyadenylation signal (spA) in exon 1 proximal to the transcription start site of HOXA11os. This results in a complete loss of HOXA11os transcripts 1 and 2 in the distal colon with no effect on the expression of the proximal protein-coding gene HOXA11 under basal or colitis conditions. (J:344661)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa11os Mutation: 0 strains or lines available

References

• Original: J:344661 Shmuel-Galia L, et al., The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis. Cell Metab. 2023 Aug 8;35(8):1441-1456.e9
• All: 1 reference(s)