Tcf23^em1Hoi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf23^em1Hoi
• Name: transcription factor 23; endonuclease-mediated mutation 1, Hisashi Oishi
• MGI ID: MGI:7738743
• Synonyms: Tcf23^-, Tcf23 KO
• Gene: Tcf23 Location: Chr5:31126006-31134362 bp, + strand Genetic Position: Chr5, 16.9 cM, cytoband B1
• Alliance: Tcf23^em1Hoi page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion of the three coding exons between the 5'UTR and 3'UTR. RT-PCR analysis showed no mRNA expression in uterine tissues from homozygous mutant females. Western bot analysis confirmed the absence of protein expression in the uterus. (J:354446)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf23 Mutation: 12 strains or lines available

References

• Original: J:354446 Minisy FM, et al., Transcription Factor 23 is an Essential Determinant of Murine Term Parturition. Mol Cell Biol. 2024;44(8):316-333
• All: 1 reference(s)