Mir30a^em1Hars
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir30a^em1Hars
• Name: microRNA 30a; endonuclease-mediated mutation 1, Sean M Hartig
• MGI ID: MGI:7738842
• Synonyms: miR-30a^-
• Gene: Mir30a Location: Chr1:23311350-23311420 bp, + strand Genetic Position: Chr1, 9.53 cM
• Alliance: Mir30a^em1Hars page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5'-ACTCCCGCAGAGCACTTCTCAGG-3' and 5'-TCAAGGAGTAATTATCTTGTTGG-3' flanking a 1-kb genomic region generated a knock-out allele. (J:344866)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir30a Mutation: 3 strains or lines available

References

• Original: J:344866 Cox AR, et al., The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice. Cell Metab. 2022 Oct 10
• All: 2 reference(s)