Upk1a^em2Mgef
Endonuclease-mediated Allele Detail

Summary

• Symbol: Upk1a^em2Mgef
• Name: uroplakin 1A; endonuclease-mediated mutation 2, Mouse Genome Engineering Facility
• MGI ID: MGI:7748716
• Synonyms: Upk1a^-
• Gene: Upk1a Location: Chr7:30302517-30312159 bp, - strand Genetic Position: Chr7, 18.78 cM
• Alliance: Upk1a^em2Mgef page

Mutation origin

• Strain of Origin: C57BL/6NJNcbs

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of the region between 392 and 557 (166 bp) that spans a part of intron 1 and exon 2 and part of intron 2. (J:345207)

Expression

In Structures Affected by this Mutation:

21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upk1a Mutation: 18 strains or lines available

References

• Original: J:345207 Munipalli SB, et al., Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome. Reprod Sci. 2023 Mar;30(3):914-927
• All: 1 reference(s)