Smlr1^em1Jaku
Endonuclease-mediated Allele Detail

Summary

• Symbol: Smlr1^em1Jaku
• Name: small leucine-rich protein 1; endonuclease-mediated mutation 1, Jan Kuivenhoven
• MGI ID: MGI:7748717
• Gene: Smlr1 Location: Chr10:25403841-25412165 bp, - strand Genetic Position: Chr10, 12.26 cM
• Alliance: Smlr1^em1Jaku page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to generate a knockout allele. (J:344880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smlr1 Mutation: 2 strains or lines available

References

• Original: J:344880 van Zwol W, et al., Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. Hepatology. 2023 Nov 1;78(5):1418-1432
• All: 1 reference(s)