Kank4^em1Jhhu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kank4^em1Jhhu
• Name: KN motif and ankyrin repeat domains 4; endonuclease-mediated mutation 1, Junhao Hu
• MGI ID: MGI:7748760
• Gene: Kank4 Location: Chr4:98643135-98705774 bp, - strand Genetic Position: Chr4, 45.6 cM
• Alliance: Kank4^em1Jhhu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an 11 bp deletion in exon 3 resulting in a frame-shift mutation. Absence of protein was confirmed in isolated brain and glomerular endothelial cells in homozygotes. (J:326312)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kank4 Mutation: 83 strains or lines available

References

• Original: J:326312 Zhang C, et al., KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner. Arterioscler Thromb Vasc Biol. 2022 Jun;42(6):772-788
• All: 1 reference(s)