Kansl1^em1.1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kansl1^em1.1Cya
• Name: KAT8 regulatory NSL complex subunit 1; endonuclease-mediated mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7751439
• Gene: Kansl1 Location: Chr11:104224055-104359687 bp, - strand Genetic Position: Chr11, 67.79 cM
• Alliance: Kansl1^em1.1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The floxed region was removed via cre-mediated recombination. (J:327464)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kansl1 Mutation: 146 strains or lines available

References

• Original: J:327464 Li T, et al., Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Nat Commun. 2022 Feb 17;13(1):931
• All: 1 reference(s)