Saa^em1.1Hiras
Endonuclease-mediated Allele Detail

Summary

• Symbol: Saa^em1.1Hiras
• Name: serum amyloid A cluster; endonuclease-mediated mutation 1.1, Sachie Hiratsuka
• MGI ID: MGI:7763990
• Gene: Saa Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Saa^em1.1Hiras involves 6 genes/genome features (Saal1, Saa3, Saa4 ...) View all
• Mutation details: CRISPR/cas9-mediated recombination using guide sequences (5-GTCCCCCCGACCCGTATGCAAGG-3 and 5-AGCGTTTATTTGACTCGTACAGG-3) inserted loxP sites in Saal1 and Saa2. Cre-mediated recombination deleted a ~70 kbp region including all the cluster genes (J:355692)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Saa Mutation: 0 strains or lines available

References

• Original: J:355692 Han Y, et al., Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis. Nat Commun. 2023 Aug 24;14(1):4960
• All: 1 reference(s)