Cyp2c70^em1Sjka
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp2c70^em1Sjka
• Name: cytochrome P450, family 2, subfamily c, polypeptide 70; endonuclease-mediated mutation 1, Saul J Karpen
• MGI ID: MGI:7764503
• Gene: Cyp2c70 Location: Chr19:40141805-40175730 bp, - strand Genetic Position: Chr19, 34.24 cM, cytoband C3
• Alliance: Cyp2c70^em1Sjka page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1,277 bp deletion that includes exon 2. The predicted transcript is a frameshift at amino acid position 57 and premature stop at codon 78. (J:330641)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2c70 Mutation: 38 strains or lines available

References

• Original: J:330641 Truong JK, et al., Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury. J Lipid Res. 2022 Aug 5;63(9):100261
• All: 1 reference(s)