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Cyp2c70em1Sjka
Endonuclease-mediated Allele Detail
Summary
Symbol: Cyp2c70em1Sjka
Name: cytochrome P450, family 2, subfamily c, polypeptide 70; endonuclease-mediated mutation 1, Saul J Karpen
MGI ID: MGI:7764503
Gene: Cyp2c70  Location: Chr19:40141805-40175730 bp, - strand  Genetic Position: Chr19, 34.24 cM, cytoband C3
Alliance: Cyp2c70em1Sjka page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology generated a 1,277 bp deletion that includes exon 2. The predicted transcript is a frameshift at amino acid position 57 and premature stop at codon 78. (J:330641)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp2c70 Mutation:  38 strains or lines available
References
Original:  J:330641 Truong JK, et al., Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury. J Lipid Res. 2022 Aug 5;63(9):100261
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory