Tex46^em1Ncvc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tex46^em1Ncvc
• Name: testis expressed 46; endonuclease-mediated mutation 2, National Cerebral and Cardiovascular Center
• MGI ID: MGI:7764802
• Synonyms: Tex46^-2376
• Gene: Tex46 Location: Chr4:136337748-136340537 bp, + strand Genetic Position: Chr4, 68.92 cM, cytoband D3
• Alliance: Tex46^em1Ncvc page

Mutation origin

• Strain of Origin: C57BL/6 x DBA/2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2376 bp deletion that consists of a 5 bp deletion (TTGGC within exon 1) and a deletion spanning the first intron (2068 bp/2107 bp coding exon) to the second exon (303 bp deletion/309 bp coding exon). (J:355678)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex46 Mutation: 10 strains or lines available

References

• Original: J:355678 Fujihara Y, et al., Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida. PNAS Nexus. 2024 Mar;3(3):pgae108
• All: 1 reference(s)