Igha^em2(cre)Xidw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igha^em2(cre)Xidw
• Name: immunoglobulin heavy constant alpha; endonuclease-mediated mutation 2, Xiaodong Wang
• MGI ID: MGI:7767879
• Synonyms: Igha-Cre
• Gene: Igha Location: Chr12:113219824-113223856 bp, - strand Genetic Position: Chr12, 62.09 cM
• Alliance: Igha^em2(cre)Xidw page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Igha^em2(cre)Xidw expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Igha (MGI:96444)

• A P2A tag and cre recombinase were added to the C terminal of Igha using CRISPR/Cas9 technology. (J:357355)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Igha (mouse) Summary of all recombinase alleles driven by Igha. Alliance mouse Igha gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igha Mutation: 18 strains or lines available

References

• Original: J:357355 Li Y, et al., Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging. iScience. 2023 Oct 20;26(10):107747
• All: 1 reference(s)