Hnrnph1^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Hnrnph1^tm1.1Nju
• Name: heterogeneous nuclear ribonucleoprotein H1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7768008
• Synonyms: Hnrnph1^flox
• Gene: Hnrnph1 Location: Chr11:50267817-50277355 bp, + strand Genetic Position: Chr11, 30.56 cM, cytoband B1.2
• Alliance: Hnrnph1^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333262
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NGpt

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin selection cassette and loxP site were inserted upstream of exon 6 and second loxP was inserted downstream of exon 6. The neomycin selection cassette was removed via flp-mediated recombination, leaving exon 6 floxed. (J:333262)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnph1 Mutation: 28 strains or lines available

References

• Original: J:333262 Feng S, et al., hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
• All: 1 reference(s)