Lcn9^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lcn9^em2Osb
• Name: lipocalin 9; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7780149
• Synonyms: (Lcn8-10/9)^del
• Gene: Lcn9 Location: Chr2:25713165-25715549 bp, + strand Genetic Position: Chr2, 18.15 cM, cytoband A3
• Alliance: Lcn9^em2Osb page

Mutation origin

• Strain of Origin: B6;D2-Del(2Lcn8-Lcn10)10Osb/Osb

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Lcn9^em2Osb involves 5 genes/genome features (Lcn8, Lcn5, Lcn6 ...) View all
• Mutation details: Lcn9 exons 1-6 were deleted in zygotes carrying the Del(2Lcn8-Lcn10)10Osb deletion via CRISPR/Cas9 technology generating a deletion of Lcn8, Lcn5, Lcn6, Lcn10, and Lcn9. (J:340906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcn9 Mutation: 18 strains or lines available

Notes

This allele contains Del(2Lcn8-Lcn10)10Osb and generates quintuple Lcn9, Lcn8, Lcn5, Lcn6 and Lcn10 knock-out mice.

References

• Original: J:340906 Sakurai N, et al., CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice. Andrology. 2022 Nov 25
• All: 1 reference(s)