Wsb1^tm1.1Jszh
Targeted Allele Detail

Summary

• Symbol: Wsb1^tm1.1Jszh
• Name: WD repeat and SOCS box-containing 1; targeted mutation 1.1, Jin-San Zhang
• MGI ID: MGI:7782525
• Synonyms: Wsb1^flox
• Gene: Wsb1 Location: Chr11:79130198-79145497 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5
• Alliance: Wsb1^tm1.1Jszh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358004
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a neomycin selection cassette flanked by self-deletion anchor sites and second loxP site were inserted downstream of exon 3. The neomycin selection cassette self-deleted. (J:358004)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wsb1 Mutation: 25 strains or lines available

References

• Original: J:358004 Chong L, et al., WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis. Am J Pathol. 2024 May;194(5):656-672
• All: 1 reference(s)