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Mir497em1Hgyu
Endonuclease-mediated Allele Detail
Summary
Symbol: Mir497em1Hgyu
Name: microRNA 497; endonuclease-mediated mutation 1, Honggang Yu
MGI ID: MGI:7782629
Gene: Mir497  Location: Chr11:70125543-70125626 bp, + strand  Genetic Position: Chr11, 42.99 cM
Alliance: Mir497em1Hgyu page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology using sgRNAs GCCTGCTAAACTACTTTTGC and GTTGTCTGATACCAGTTATC deleted the entire sequence. (J:357958)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
C57BL/6-Mir497em1Hgyu
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
digestive/alimentary system
increased susceptibility to induced colitis
immune system
increased susceptibility to induced colitis
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir497 Mutation:  2 strains or lines available
References
Original:  J:357958 Zhang M, et al., MicroRNA-497 inhibits inflammation in DSS-induced IBD model mice and lipopolysaccharide-induced RAW264.7 cells via Wnt/beta-catenin pathway. Int Immunopharmacol. 2021 Dec;101(Pt B):108318
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory