Arid3c^em1Fclo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arid3c^em1Fclo
• Name: AT-rich interaction domain 3C; endonuclease-mediated mutation 1, Frederic Clotman
• MGI ID: MGI:7783477
• Synonyms: Arid3c^-
• Gene: Arid3c Location: Chr4:41723836-41731142 bp, - strand Genetic Position: Chr4, 22.01 cM
• Alliance: Arid3c^em1Fclo page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Pronuclear injection of two Ultramers-loxP sequences, two Arid3c cRNAs and Cas9 targeting exon 2 generated the removal of exon 2 after non homologous end joining using CRISPR/Cas9 technology. The removal of exon 2 leads to a frameshift and generates a STOP codon, which causes a loss of 74% of the C-terminal part of the protein, including the ARID and REKLES domains. (J:357897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid3c Mutation: 21 strains or lines available

References

• Original: J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056
• All: 1 reference(s)