Itih5^tm1Jmba
Targeted Allele Detail

Summary

• Symbol: Itih5^tm1Jmba
• Name: inter-alpha-trypsin inhibitor, heavy chain 5; targeted mutation 1, Jens M Baron
• MGI ID: MGI:7786763
• Gene: Itih5 Location: Chr2:10158382-10261340 bp, + strand Genetic Position: Chr2, 6.94 cM
• Alliance: Itih5^tm1Jmba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:359049
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 5 kb of the sequence upstream of exon 1 (proximal promoter region) was replaced with a F3 site-flanked puromycin resistance cassette expressed under the control of an eukaryotic CAGGAS promoter and containing a polyadenylation signal. (J:359049)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itih5 Mutation: 46 strains or lines available

References

• Original: J:359049 Huth S, et al., Inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models. Exp Dermatol. 2015 Sep;24(9):663-8
• All: 2 reference(s)