Myorg^em#Zqx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Myorg^em#Zqx
• Name: myogenesis regulating glycosidase (putative); endonuclease-mediated mutation, Zhi-Qi Xiong
• MGI ID: MGI:7787039
• Gene: Myorg Location: Chr4:41495604-41503076 bp, - strand Genetic Position: Chr4, 21.69 cM
• Alliance: Myorg^em#Zqx page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting using two different sgRNA sequences (sgRNA1 5'-CTGCTGTGCTCCGCGGTACT-3' and sgRNA2 5'-TTCTCCATCCGTAACCAGAA-3'), targeting different genomic loci of Myorg (position c.166-185 and position c.295-314) were used to generate early frame-shift mutations. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:269369)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myorg Mutation: 37 strains or lines available

References

• Original: J:269369 Yao XP, et al., Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification. Neuron. 2018 Jun 27;98(6):1116-1123.e5
• All: 2 reference(s)