Tmc7^em1Zjl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmc7^em1Zjl
• Name: transmembrane channel-like gene family 7; endonuclease-mediated mutation 1, Zhaojian Liu
• MGI ID: MGI:7787153
• Gene: Tmc7 Location: Chr7:118135064-118183959 bp, - strand Genetic Position: Chr7, 63.44 cM
• Alliance: Tmc7^em1Zjl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a partial deletion of exon 2 (first 241 bp). (J:359286)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmc7 Mutation: 41 strains or lines available

References

• Original: J:359286 Wang J, et al., TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice. Elife. 2024 Sep 13;13
• All: 1 reference(s)